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Figure 7 | Journal of Inflammation

Figure 7

From: Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model

Figure 7

Effects of CRMP2 silence on left ventricular fibrosis and heart function after MI in ApoE −/− mice. A. Representative Masson’s trichrome staining revealed left ventricular fibrosis 4 weeks after MI (magnification: 4x). Scale bar indicates 500 μm. B. Quantitative analysis of the scar area (n = 10, *p < 0.05). C. Quantification of left ventricular end diastolic diameter (LVEDd). D. Quantification of left ventricular end systolic diameter (LVESd), E. Quantification of left ventricular ejection fraction. F. Quantification of fractional shortening (n = 30, *p < 0.05 vs. control). G. Kaplan–Meier survival curves in siCON and siCRMP2 groups with MI (n = 30 per group, *p < 0.05 vs. control).

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