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Figure 6 | Journal of Inflammation

Figure 6

From: Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model

Figure 6

CRMP2 RNAi reduced the expression of fibrosis and inflammation markers in ApoE −/− mice with MI. Expression of different fibrosis and inflammation markers was analyzed by quantitative real-time PCR in myocardial samples from the infarct region (Infarct), infarct border zone (Border), and area remote to the infarct (Remote) 7 and 28 days after infarction. A. Fibroblast proliferation marker Thy1. B. Collagen 1a1 (Col1a1). C. Lysyl oxidase (Lox). D. Neutrophil marker granzyme B (Gzmb). E. Macrophage marker CD68. F. Proinflammatory cytokine interleukin-6 (IL-6). Results are expressed as fold induction ± SE over the uninjured values. *P < 0.05 compared to siCON group.

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Journal of Inflammation

ISSN: 1476-9255

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