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Figure 2 | Journal of Inflammation

Figure 2

From: Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model

Figure 2

CRMP2 RNAi promoted M1 to M2 switch. A. Western blot analysis indicated that knockdown of CRMP2 with three siRNAs in M1 macrophages resulted in marked decrease in the expression of CD86 but increase in the expression of CD163. Shown are representative data from three independent experiments with similar results. B. Flow cytometry images showed that CRMP2 RNAi with a mixture of three siRNAs in M1 macrophages resulted in a marked decrease in the expression of CD86 but an increase in the expression of CD163. Shown are representative data from three independent experiments with similar results. C & D. Gene expression analysis of selected M1- and M2-associated transcripts in macrophages after being treated with control siRNA or CRMP2 siRNA. Data were mean ± SEM from three independent experiments. *p < 0.05 compared with control.

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