Figure 7
LPS-induced endotoxin shock. BALB/c mice were intravenously administered saline or ANO (68 mg/kg or 135 mg/kg) immediately before intraperitoneal injection with LPS (18 mg/kg) (n = 6 mice in each group) (A). In a separate experiment, ANO (200 mg/kg) was administered orally 1 h before and 1 and 6 h after LPS injection (n = 8 mice in each group) (B). Survival of mice was monitored for 3 days after LPS injection. Results are representative of two separate experiments with similar results. **p < 0.01, significantly different when compared with vehicle control.