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Figure 8 | Journal of Inflammation

Figure 8

From: Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation

Figure 8

Effects of allosteric enhancement on circulating plasma cytokines and chemokines in the LPS- induced mouse model of endotoxemia. Study groups consisted of male age matched control BALB/cJ mice (open bars; A- C) and A2AR-deficient mice (closed bars; D- F). Animals were administered either vehicle or AEA061 (0.1, 1 and 10 mg/kg) iv 10 min prior to ip injection of LPS (20 mg/kg). Plasma cytokine/chemokine levels were quantified 2 h after LPS dosing as described in Materials and Methods. Mean plasma cytokine/chemokine levels ± SEMs of 10–14 animals per treatment group are indicated. Statistical difference between the vehicle and the treatment groups were determined by one-way ANOVA; *, p <0.05 and **, p <0.01.

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