Figure 7
From: Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation
Reversal of AEA061-mediated inhibition of TNF- α production by ZM 241385. Human monocytes were pretreated for 15 min with the A2AR antagonist ZM 241385 before PMA stimulation (5 ng/ml) and incubation with either the AR agonist NECA (1 μM; A) or AEA061 (1 μM; B) for 12 h. TNF-α in the culture medium was quantified by ELISA. # = p <0.001 PMA versus PMA plus AEA061 or NECA; * = p <0.05, ** = p <0.01 *** = p <0.001 PMA plus AEA061 or NECA with ZM versus without ZM.