N = 6/group. Median (range) | ||||||
---|---|---|---|---|---|---|
Small intestine | Oral buccal mucosa | |||||
Sham | IR | IR + selenium | Sham | IR | IR + selenium | |
GSH level (pmol/mg tissue) | 460 (404–580) | 400 (385–455) | 401 (339–427) | 509 (444–555) | 468 (449–540) | 448 (429–478) |
GSSG level (pmol/mg tissue) | 397 (322–457) | 382 (348–419) | 447✝(418–467) | 387 (337–438) | 354 (321–399) | 392 (360–416) |
GPx activity (mU/mg tissue) | 3.06 (2.63-3.12) | 2.72 (2.34-2.94) | 3.47*✝(3.20-3.82) | 3.26 (2.90-3.34) | 2.60*(2.30-2.77) | 2.90✝(2.76-3.16) |
MDA level (pmol/mg tissue) | 118 (110–134) | 1113*(849–1258) | 395*✝(178–471) | 41 (21–58) | 119*(106–134) | 94*✝(48–108) |
p-IκB-α expression (OD) | 1.00 (0.53-1.28) | 1.87*(1.49-2.50) | 1.06✝(0.60-1.29) | 0.23 (0.07-0.35) | 1.45*(1.04-2.42) | 0.52✝(0.31-0.83) |
IκB-α expression (OD) | 1.00 (0.88-1.28) | 0.22*(0.12-0.44) | 0.92✝(0.68-1.56) | 0.48 (0.37-0.65) | 0.20*(0.20-0.36) | 0.48✝(0.32-0.58) |
NF-κB p65 expression (OD) | 1.00 (0.78-1.70) | 17.40*(9.93-17.69) | 3.77*✝(3.63-4.62) | 0.33 (0.08-0.59) | 8.44*(7.15-9.93) | 2.32*✝(1.73-3.16) |
NF-κB p65 DNA-binding (OD) | 1.00 (0.90-1.23) | 2.65*(1.80-2.93) | 1.62*✝(1.20-2.03) | 0.47 (0.47-0.50) | 0.59*(0.54-0.67) | 0.51✝(0.47-0.54) |
Sham | IR | IR + selenium | ||||
Serum TNF-α level (pg/mL) | 32.35 (31.08-34.90) | 226.60 (183.46-330.04) | 155.33 (129.01-203.32) |