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Table 3 Multiple regression models for spontaneous and stimulated monocyte production of H 2 O 2

From: Increased production of hydrogen peroxide by peripheral blood monocytes associated with smoking exposure intensity in smokers

Model Coefficient Coefficient
  95% confidence interval 95% confidence interval
  Spontaneous production H 2 O 2 Stimulated production H 2 O 2
Pack-years 0.03(0.01; 0.05) 0.04(−0.03; 0.10)
Pack-years 0.03(0.001; 0.05) 0.06(−0.02; 0.14)
TNF-α serum (pg/ml) −0.19(−0.85; 0.48) −0.48(−1.35; 0.39)
Pack-years 0.02(0.001; 0.04) 0.04(−0.03; 0.11)
TNF-α monocytes (pg/ml) −0.0007(−0.002; 0.0007) −0.001(−0.009; 0.004)
Pack-years 0.02(0.005; 0.06) 0.03(−0.03; 0.10)
IL-6 serum (pg/ml) 0.19(−0.40; 0.77) 0.61(−1.21; 2.43)
Pack-years 0.0(0.005; 0.05) 0.06(−0.006; 0.13)
IL-6 monocytes (pg/ml) −1.5e-04(−3.7e-04; 6.5e-06) −2.5e-04(−9.1e-04; 4.0e-04)
Pack-years 0.02(−0.004; 0.04) 0.01(−0.06; 0.09)
Neutrophils (cel/mm3) 0.0001(−0.00002; 0.0003) 0.0005(−0.0002; 0.001)
  1. H2O2: peroxide hydrogen; TNF- α: tumor necrosis factor alpha; IL-6: interleukin 6. Monocyte production of H2O2 was stimulated by phorbol myristate acetate.
  2. All of the multiple regression models with robust standard errors were adjusted for potential confounding variables (age, gender, forced expiratory volume in the first second and body mass index).