From: A new metabolomic assay to examine inflammation and redox pathways following LPS challenge
Metabolite | Controla (nmol/mg protein) | LPSb (nmol/mg protein) | % CHANGEc from Control | Pathwayd | Sige |
---|---|---|---|---|---|
Cit | 0.2 ± 0.02 | 10.3 ± 1.8 | 5050.0 | Arg Met | < 0.0001 |
Orn | 0.7 ± 0.3 | 5.78 ± 0.8 | 752.9 | Arg Met | < 0.0001 |
Put | 1.2 ± 0.2 | 7.5 ± 2.4 | 525.0 | Arg Met | < 0.0001 |
Cys | 2.1 ± 0.7 | 6.2 ± 1.7 | 195.2 | SAA Met | < 0.01 |
Gln | 6.2 ± 0.5 | 16.1 ± 0.5 | 159.7 | Arg Met | < 0.01 |
Ile+Leu | 1.3 ± 0.2 | 3.3 ± 0.8 | 153.8 | BCAA | < 0.05 |
Phe | 0.6 ± 0.6 | 1.0 ± 0.3 | 66.7 | EAA | < 0.05 |
Hcy | 0.03 ± 0.01 | 0.05 ± 0.02 | 66.7 | SAA Met | < 0.05 |
Ser | 1.6 ± 0.2 | 2.2 ± 0.4 | 37.5 | SAA Met | < 0.05 |
Met | 4.0 ± 0.4 | 5.4 ± 0.3 | 35.0 | SAA Met | < 0.05 |
GSSG | 0.4 ± 0.1 | 0.5 ± 0.1 | 25.0 | SAA Met | < 0.05 |
Asn | 2.3 ± 0.3 | 2.6 ± 0.5 | 13.0 |  |  |
Pro | 5.4 ± 1.6 | 6.0 ± 1.3 | 11.1 |  |  |
Lys | 13.23 ± 2.85 | 14.61 ± 4.34 | 10.4 |  |  |
Ala | 3.3 ± 0.8 | 3.6 ± 0.34 | 9.1 |  |  |
His | 1.5 ± 0.5 | 1.6 ± 0.2 | 6.7 |  |  |
Spd | 13.3 ± 2.1 | 13.7 ± 2.3 | 3.0 |  |  |
Trp | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.0 |  |  |
Tyr | 0.7 ± 0.3 | 0.7 ± 0.24 | 0.0 |  |  |
Val | 0.7 ± 0.3 | 0.7 ± 0.2 | 0.0 |  |  |
SAM | 0.2 ± 0.04 | 2.2 ± 0.2 | −7.1 |  |  |
Thr | 9.2 ± 2.5 | 8.3 ± 1.9 | −9.8 |  |  |
GSH | 46.8 ± 2.4 | 37 ± 4.9 | −20.9 | SAA Met | < 0.05 |
Glu | 37.5 ± 3.8 | 24.9 ± 5.2 | −33.6 | SAA Met | < 0.05 |
Gly | 25.4 ± 1.0 | 16.0 ± 1.1 | −37.0 | SAA Met | < 0.05 |
SAH | 0.2 ± 0.03 | 0.1 ± 0.02 | −50.0 | SAA Met | < 0.01 |
Spm | 23.8 ± 1.5 | 8.23 ± 6.2 | −65.4 | Arg Met | < 0.01 |
Arg | 3.2 ± 0.13 | 1.1 ± 0.11 | −65.6 | Arg Met | < 0.0001 |
Asp | 57.8 ± 13.8 | 15.8 ± 4.0 | −72.7 | Arg Met | < 0.0001 |