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Figure 1 | Journal of Inflammation

Figure 1

From: A new metabolomic assay to examine inflammation and redox pathways following LPS challenge

Figure 1

Metabolites and their metabolic pathway networks measured by the Arg/Thiol Redox Metabolomics Assay. The assay covers nearly all Arg metabolic pathways (rectangle), including the arginase, Cit-NO cycle, and polaymine pathways (hexagon). Also shown are sulfur amino acid derived sulfhydryl containing redox metabolites (grey ovals), and names of enzymes involved in the synthesis pathways. Argininosuccinate (dotted rectangle box) was not measured. Some major amino acids (circles) were measured but are not shown in this figure (See Table1 for a complete list of analytes quantified). Compounds that were significantly decreased or increased after 24 hrs of treatment with LPS (1000 ng/ml) are highlighted with - or +, respectively. Abbreviations: Alanine – Ala; Arginine – Arg; Asparagine – Asn; Aspartate – Asp; Argninosuccinate Lyase - ASL; Argininosuccinate Synthetase – ASS; Betaine Hydroxymethyl Transferase - BHMT; Citrulline – Cit; Cysteine – Cys; Cystathionine Beta-synthase - CBS; Cystathionine Lyase - CL; γ-Glutamyl Transpeptidase – GGT; γ-Glutamylcysteine Ligase – GCL; Glutathione – GSH; Glutathione disulfide – GSSG; Glutathione synthase - GS ; Glutamate – Glu; Glutamine – Gln; Glutamine Synthase - Gln Syn; Glycine – Gly; Histidine – His; Homocysteine – Hcy; Methionine – Met; Methionine Adenosyl Transferase – MAT; Methyl Transferase - MT; Methionine Synthase - MS; Nitric Oxide Synthase - NOS; Ornithine – Orn; Ornithine Decarboxylase - ODC; Proline - Pro; Putrescine – Put; Polyamine Oxidase - PAO; S-adenosylmethionine – SAM; S-Adenosylmehtionine Decarboxylase - SAMDC; S-adenosylhomocysteine – SAH; S-Adenosylhomocysteine hydrolyase - SAHH; Serine – Ser; Spermidine – Spd; Spermidine Synthase - Spd Syn; Spermine synthase - Spm Syn; Spermine – Spm; Spermidine/Spermine N1 acetyltransferase - SSAT.

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