Table 2 Outcome measures on D1 and D84 (Mean ± SEM)
|  | Placebo Group (n = 11) | MMPI Group (n = 9) | |||
|---|---|---|---|---|---|
Measures | Control | D1 | D84 | D1 | D84 |
CRP | 1.9 ± 0.8 | 5.9 ± 1.8* | 6.2 ± 1.8* | 7.4 ± 3.3* | 2.3 ± 0.4†|
MPO | 68.8 ± 6.6 | 88.6 ± 6.0* | 94.5 ± 11.3* | 110.2 ± 15.3* | 91.6 ± 13.6†|
SBP (mmHg) | 115.7 ± 19.6 | 127.7 ± 5.7 | 133.4 ± 4.8 | 136.2 ± 6.5 | 137.5 ± 5.8 |
DBP (mmHg) | 72.0 ± 10.5 | 77.0 ± 10.1 | 77.8 ± 11 | 77.8 ± 8.0 | 77.4 ± 11.2 |
TC (mg/dL) | 177.5 ± 28.0 | 178.8 ± 13 | 152.2 ± 6 | 177.9 ± 14 | 165.1 ± 10 |
HDL (mg/dL) | 54.0 ± 15.2 | 40.5 ± 3.2** | 36.58 ± 3.0** | 38.44 ± 2.6** | 38.44 ± 3.2** |
LDL (mg/dL) | 106.7 ± 22.2 | 99.6 ± 12 | 82 ± 7 | 86 ± 9 | 86.4 ± 8.8 |
TG (mg/dL) | 84.4 ± 39.0 | 209.1 ± 30** | 191.5 ± 36** | 235.9 ± 48** | 188.6 ± 37** |
AST (IU/L) | 22.8 ± 7.7 | 30.8 ± 4.1 | 33.0 ± 6.1 | 24.4 ± 2.9 | 20.1 ± 1.4 |
Creatinine (mg/dL) | 0.9 ± 0.2 | 0.83 ± 0.05 | 0.83 ± 0.07 | 0.91 ± 0.05 | 0.92 ± 0.06 |
Fasting glucose (mmol/L) | 5.1 ± 1.2 | 9.4 ± 0.5** | 8.8 ± 0.6** | 8.0 ± 0.7** | 8.0 ± 1.0** |
A1C (%) | 5.4 ± 0.2 | 8.6 ± 0.4 | 8.0 ± 0.3 | 8.3 ± 0.6 | 7.8 ± 0.4 |
AUCi | 0.25 ± 0.07 | 0.57 ± 0.16 | 0.57 ± 0.13* | 0.89 ± 0.31* | 0.71 ± 0.29 |
HOMA-IS | 53.4 ± 7.6 | 135.3 ± 32.7 | 164 ± 46.8 | 244.9 ± 98.5 | 433.1 ± 272.1 |
HOMA-IR | 1.06 ± 0.1 | 21 ± 5.1 | 26 ± 9.8 | 14.3 ± 4.7 | 23.0 ± 11.1 |
ΔI30–0/ΔG30–0 | 98 ± 17.5 | 37.3 ± 51.1 | 54.3 ± 30 | 73.7 ± 35.9 | 16.6 ± 20.1†|
Global MMP (uM 5-FAM/h-ug protein) | 47.2 ± 3.2 | 43.8 ± 4 | 56.6 ± 10.1 | 56.8 ± 13.3 | 59.7 ± 4.3 |
IL-1β (pg/ml) | 0.15 ± 0.06 | 0.14 ± 0.05 | 0.13 ± 0.04 | 0.27 ± 0.15 | 0.46 ± 0.22 |
IL-2 (pg/ml) | 1.8 ± 0.6 | 1.1 ± 0.4 | 0.9 ± 0.3 | 0.7 ± 0.3 | 1.1 ± 0.4 |
IL-4 (pg/ml) | 10.0 ± 2.5 | 7.3 ± 2.1 | 9.9 ± 4.5 | 9.8 ± 4.2 | 7.4 ± 2.3 |
IL-6 (pg/ml) | 6.9 ± 1.5 | 5.3 ± 1.9 | 8.4 ± 3.5 | 10.9 ± 4.3 | 12.9 ± 5.4 |
IL-8 (pg/ml) | 2.4 ± 0.4 | 2.8 ± 0.5 | 3.2 ± 0.5 | 4.8 ± 0.9 | 5.8 ± 1.0 |
IL-10 (pg/ml) | 16.6 ± 3.8 | 15.1 ± 3.5 | 11.3 ± 3.0†| 16.4 ± 5.2 | 16.8 ± 3.8 |
TNF-α (pg/ml) | 4.7 ± 0.6 | 4.4 ± 0.4 | 4.4 ± 0.7 | 6.6 ± 1.3 | 5.8 ± 1.1 |