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Table 3 Effects of IL-1β stimulation on mRNA levels of candidate genes after 6 hours

From: Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

Gene Mean (Fold Change) SEM p-Value
IL-1β 246.34 48.12 <0.001
IL-6 2895.17 1571.28 <0.001
IL-8 241.89 56.71 <0.001
MMP1 166.05 31.06 <0.001
MMP3 260.58 70.75 <0.001
MMP13 119.06 29.49 <0.001
TNF-α 21.45 7.16 <0.001
TLR2 8.49 1.64 <0.001
  1. Data was obtained by real-time RT-PCR (ΔΔct method) (n = 10).