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Table 3 Effects of IL-1β stimulation on mRNA levels of candidate genes after 6 hours

From: Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

Gene

Mean (Fold Change)

SEM

p-Value

IL-1β

246.34

48.12

<0.001

IL-6

2895.17

1571.28

<0.001

IL-8

241.89

56.71

<0.001

MMP1

166.05

31.06

<0.001

MMP3

260.58

70.75

<0.001

MMP13

119.06

29.49

<0.001

TNF-α

21.45

7.16

<0.001

TLR2

8.49

1.64

<0.001

  1. Data was obtained by real-time RT-PCR (ΔΔct method) (n = 10).
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Journal of Inflammation

ISSN: 1476-9255

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