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Figure 5 | Journal of Inflammation

Figure 5

From: Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

Figure 5

Effects of curcumin (5, 10 or 20 μM) on mRNA levels of candidate genes after 6 hours, indicated as fold change relative to IL-1β-treatment: MMP1 (5a); MMP3 (5b); MMP13 (5c); Interleukin-1β (5d); Interleukin-6 (5e); Interleukin-8 (5f); TNF-α (5g); TLR2 (5h) (IL-1β treated cells also contain 0.03% of DMSO). Data was obtained by real-time RT-PCR (2-ΔΔCt method) and is presented as Mean and SEM (n = 5). Asterisks indicate statistical significance (p < 0.05). Each gene was normalized to its respective IL-1β treatment (IL-1β + DMSO), which was always set to 100% (only one exemplary control bar is shown).

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Journal of Inflammation

ISSN: 1476-9255

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