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Table 1 Physical and Demographic Characteristics

From: 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors

Parameter

Control

HIV+

p-value

N (% female)

5 (20)

9 (11)

1.0

Ethnicity

All Caucasian

7 Cauc. 2 African American

0.51

Age (yrs)

44 ± 3 (46, 35, 51)

52 ± 3 (52, 38, 67)

0.07

# Yrs Known HIV+

0

14 ± 2 (13, 7, 20)

<0.01

CD4+ (cells/μL)

nd

771 ± 132 (655, 622, 1035)

 

Plasma HIV RNA (copies/mL)

nd

All <50

 

History Hypertension (%)

0

78

0.02

Family History Diabetes (%)

0

56

0.08

History Hyperlipidemia (%)

20

44

0.58

Current tobacco smoker (%)

0

33

0.26

# Yrs Smoker

0

21 ± 4 (22, 10, 30)

<0.01

Packs/day

0

1.4 ± 0.2 (1.3,1.0,2.0)

<0.01

BMI (kg/m2)

25 ± 1 (25, 20, 28)

29 ± 2 (26, 22, 40)

0.12

Waist circ (cm)

86 ± 3 (88, 79, 90)

101 ± 6 (95, 84, 130)

0.07

Resting Systolic BP (mmHg)

112 ± 3 (114,104,119)

129 ± 5 (128, 115, 150)

0.01

Resting Diastolic BP (mmHg)

71 ± 5 (72, 55, 88)

76 ± 3 (75, 66, 90)

0.48

Fasting Triglycerides (mg/dL)

63 ± 6 (60, 53, 79)

149 ± 35 (115, 43, 349)

0.04

HDL-cholesterol (mg/dL)

51 ± 6 (50, 37, 65)

45 ± 4 (47, 29, 68)

0.43

Total cholesterol (mg/dL)

164 ± 4 (164, 156, 172)

182 ± 9 (177, 140, 218)

0.11

Calc.LDL-cholesterol (mg/dL)

101 ± 7 (95, 91, 122)

108 ± 9 (106, 74, 156)

0.55

Framingham 10-yr Risk

2 ± 1 (1, 1, 4)

9 ± 2 (7, 1, 18)

<0.01

Carotid Ultrasound

   

Mean Right & Left Posterior CIMT (mm)

0.54 ± 0.03 (0.52, 0.45, 0.63)

0.78 ± 0.02 (0.78, 0.66, 0.90)

<0.01

Non-obstructive Plaque

0

8 (89%)

 

Glycemic Control

   

Fasting Glucose (mg/dL)

89 ± 3 (89, 81, 96)

97 ± 4 (98, 82, 114)

0.11

Fasting Insulin (μU/mL)

2.0 ± 0.1 (2, 2, 2)

13.7 ± 4.5 (9, 6, 30)

0.06

Fasting C-peptide (ng/mL)

0.9 ± 0.1 (0.9, 0.7,1.0)

4.0 ± 0.8 (3.4, 2.3, 6.5)

0.02

HOMA

0.4 ± 0.0 (0.4, 0.4, 0.5)

3.2 ± 1.1 (2.6, 1.2, 7.4)

0.07

Systemic Inflammatory Biomarkers

   

hs-CRP (mg/L)

0.8 ± 0.3 (0.8, 0.5, 1.2)

2.6 ± 2.3 (2.0, 0.6, 6.2)

0.16

D-dimer (μg FEU/mL)

0.1 ± 0.1 (0.1, 0.0, 0.2)

0.4 ± 0.5 (0.1, 0.0, 1.1)

0.27

  1. Mean ± SE (Median, Min, Max); CIMT = carotid intima media thickness; nd = not done.