Parameter | Control | HIV+ | p-value |
---|---|---|---|
N (% female) | 5 (20) | 9 (11) | 1.0 |
Ethnicity | All Caucasian | 7 Cauc. 2 African American | 0.51 |
Age (yrs) | 44 ± 3 (46, 35, 51) | 52 ± 3 (52, 38, 67) | 0.07 |
# Yrs Known HIV+ | 0 | 14 ± 2 (13, 7, 20) | <0.01 |
CD4+ (cells/μL) | nd | 771 ± 132 (655, 622, 1035) | |
Plasma HIV RNA (copies/mL) | nd | All <50 | |
History Hypertension (%) | 0 | 78 | 0.02 |
Family History Diabetes (%) | 0 | 56 | 0.08 |
History Hyperlipidemia (%) | 20 | 44 | 0.58 |
Current tobacco smoker (%) | 0 | 33 | 0.26 |
# Yrs Smoker | 0 | 21 ± 4 (22, 10, 30) | <0.01 |
Packs/day | 0 | 1.4 ± 0.2 (1.3,1.0,2.0) | <0.01 |
BMI (kg/m2) | 25 ± 1 (25, 20, 28) | 29 ± 2 (26, 22, 40) | 0.12 |
Waist circ (cm) | 86 ± 3 (88, 79, 90) | 101 ± 6 (95, 84, 130) | 0.07 |
Resting Systolic BP (mmHg) | 112 ± 3 (114,104,119) | 129 ± 5 (128, 115, 150) | 0.01 |
Resting Diastolic BP (mmHg) | 71 ± 5 (72, 55, 88) | 76 ± 3 (75, 66, 90) | 0.48 |
Fasting Triglycerides (mg/dL) | 63 ± 6 (60, 53, 79) | 149 ± 35 (115, 43, 349) | 0.04 |
HDL-cholesterol (mg/dL) | 51 ± 6 (50, 37, 65) | 45 ± 4 (47, 29, 68) | 0.43 |
Total cholesterol (mg/dL) | 164 ± 4 (164, 156, 172) | 182 ± 9 (177, 140, 218) | 0.11 |
Calc.LDL-cholesterol (mg/dL) | 101 ± 7 (95, 91, 122) | 108 ± 9 (106, 74, 156) | 0.55 |
Framingham 10-yr Risk | 2 ± 1 (1, 1, 4) | 9 ± 2 (7, 1, 18) | <0.01 |
Carotid Ultrasound | |||
Mean Right & Left Posterior CIMT (mm) | 0.54 ± 0.03 (0.52, 0.45, 0.63) | 0.78 ± 0.02 (0.78, 0.66, 0.90) | <0.01 |
Non-obstructive Plaque | 0 | 8 (89%) | |
Glycemic Control | |||
Fasting Glucose (mg/dL) | 89 ± 3 (89, 81, 96) | 97 ± 4 (98, 82, 114) | 0.11 |
Fasting Insulin (μU/mL) | 2.0 ± 0.1 (2, 2, 2) | 13.7 ± 4.5 (9, 6, 30) | 0.06 |
Fasting C-peptide (ng/mL) | 0.9 ± 0.1 (0.9, 0.7,1.0) | 4.0 ± 0.8 (3.4, 2.3, 6.5) | 0.02 |
HOMA | 0.4 ± 0.0 (0.4, 0.4, 0.5) | 3.2 ± 1.1 (2.6, 1.2, 7.4) | 0.07 |
Systemic Inflammatory Biomarkers | |||
hs-CRP (mg/L) | 0.8 ± 0.3 (0.8, 0.5, 1.2) | 2.6 ± 2.3 (2.0, 0.6, 6.2) | 0.16 |
D-dimer (μg FEU/mL) | 0.1 ± 0.1 (0.1, 0.0, 0.2) | 0.4 ± 0.5 (0.1, 0.0, 1.1) | 0.27 |