Figure 4

Correlation between clinical measure of disease and¹⁹F MRI imaging. A. Clinical measurements of disease severity manifested as ankle swelling were obtained through caliper measurements of ankle thickness and were plotted versus the total ¹⁹F spins/ankle as measured from the MRI images on day 15 (◆). Solid line represents the linear trend generated from data on individual ankles (n = 12). Two animals had very high levels of ¹⁹F found in the tail near the site of tail vein injection, suggesting that V-Sense was not delivered into the circulation. These two animals (◇) had significantly lower levels of ¹⁹F in each ankle than animals with similar clinical measurements (p < 0.001), and were not included in the linear regression. B. Representative slices from animals without (◆) and with (◇) high ¹⁹F in the tail are shown.