Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis

Table 1 WT EAMG and Crry ^−/− EAMG mice show similar disease outcome

Mouse strain	Day 14	Day 35	Day 63
WT EAMG	0.400 ± 0.22	1.000 ± 0.35	1.300 ± 0.57
Crry ^−/− EAMG	0.375 ± 0.25	0.875 ± 0.25	1.250 ± 0.50
WT Ctrl	0	0	0
Crry ^−/− Ctrl	0	0	0

EAMG clinical scores were determined at Day 0 (prior disease induction), Days 14, 35 and 63 post primary immunization. The data for each mouse strain represent the average (± SEM) in one of three representative experiments (n = 5–9 mice per group). Despite greater general weakness in Crry ^−/− EAMG, no significant changes in disease clinical scores were detected.

ISSN: 1476-9255