Figure 1
From: Murine gammaherpesvirus-68 expands, but does not activate, CD11b+ gr-1+ splenocytes in vivo
Increased percentage of splenic CD11b+Gr-1+cells during the leukocytosis phase of HV-68 infection. Groups ofBalb/c mice were mock-treated or intranasally infected with HV-68 virus. During the peak of viral-induced leukocytosis (15 days post-infection), bone marrow cells and splenocytes were isolated from individual animals and labeled with fluorchrome-conjugated anti-CD11b and anti-Gr-1 antibodies. FACS analysis of one representative animal per group shows the percentage of CD11b+ Gr-1+ cells (upper right quadrant) from thebone marrow (Panel A) or spleen (Panel C) of a mock-treated mouse, or from the bone marrow (Panel B) or spleen (Panel D) ofan HV-68 infected mouse.