Figure 2

Steatosis, inflammation and fibrosis in livers of HFC-fed mice. Liver sections from 6 (A, D, G, J), 16 (B, E, H, K, M, N) and 26 (C, F, I, L) weeks of chow (A-C, G-I, M) and HFC (D-F, J-L, N) fed mice were analyzed histologically. A-F, H&E stain. Cellular infiltrates are readily seen throughout 16 and 26 weeks of HFC livers and is illustrated in the insert of E. G-L, Oil red O stain. Increased focal fibrosis as demonstrated by trichrome stain was found in livers of some HFC-fed mice at 16 weeks (N) or later as compared to 16 week chow-fed liver (M). A-L bar = 0.15 mm. M&N, bar = 0.075 mm.