Percent body weight gain and fat mass increase in HFC-fed mice over time. A: Percent body weight gain over time. All time points plotted are P < 0.01 for 45% high fat + 0.12% cholesterol (HFC) vs. chow-diet (CHOW), Mann-Whitney U test. Animals selected at day 21 for increased body weight (DIO; diet-induced obesity). B: Body Density Parameters determined by MRI Analysis. *P < 0.0001 for fat mass of HFC vs. CHOW, Mann-Whitney U test.