Table 1 Anti-CD3 mAb- and LPS-induced cytokine expression by PBMCs derived from OMD and TMD fed subjects at various time periods during the trial.
Cytokines | Pretreatment | 1 meal, 1 month | 1 meal, 2 months | Off diet | 3 meals, 1 month | 3 meals, 2 months |
|---|---|---|---|---|---|---|
Subject Number | 15 | 8 | 12 | 12 | 12 | 12 |
IL-6 (pg/ml) Unstimulated | 520.5 ± 420.3 | 1290.2 ± 52.9 | 275.8 ± 52.9 | 871.6 ± 420.8 | 2653.8 ± 912.5 | 459.2 ± 154.3 |
IL-6 (pg/ml) Anti-CD3 mAb | 1089.2 ± 195.6 | 32794.2 ± 17902.1 | 4163.2 ± 647.5 | 19669.1 ± 13184.2 | 61393 ± 34081 | 4291.8 ± 736.4 |
IL-1β (pg/ml) Anti-CD3 mAb | 229.4 ± 47.2 | 3778.6 ± 2181.4 | 243.4 ± 61.5 | 1429.3 ± 897.6 | 4234.6 ± 1526.9 | 245.3 ± 59.8 |
IL-2 (pg/ml) Anti-CD3 mAb | 28.3 ± 5.2 | 121.5 ± 78.3 | 85.4 ± 33.2 | 174.6 ± 146.3 | 146.5 ± 63.8 | 288.4 ± 139.6 |
GM-CSF (pg/ml) Anti-CD3 mAb | 45.2 ± 4.2 | 279.8 ± 12.7 | 44.6 ± 7.8 | 347.3 ± 263.5 | 679.1 ± 259.6 | 109.3 ± 55.96 |
GM-CSF (pg/ml) LPS | 63.2 ± 11.5 | 169.3 ± 96.8 | 74.6 ± 12.3 | 82.6 ± 22.3 | 934.6 ± 50.7 | 274.3 ± 169.5 |
G-CSF (pg/ml) Anti-CD3 mAb | 98.4 ± 62.3 | 264.5 ± 146.3 | 55.6 ± 12.1 | 103.6 ± 62.2 | 405.9 ± 125.4 | 54.2 ± 16.2 |
G-CSF (pg/ml) LPS | 1075.4 ± 221.1 | 7912 ± 5880.1 | 2195.3 ± 374.6 | 2669.4 ± 1008.6 | 10608.2 ± 4633.8 | 4466.1 ± 2213.5 |
IL-10 (pg/ml) Anti-CD3 mAb | 270.5 ± 63.1 | 3960.1 ± 3103 | 381.7 ± 81.6 | 2055.4 ± 1699.5 | 4404.5 ± 1398.9 | 524.5 ± 212.6 |