Table 1 Cumulative chart score of histological findings (Arbitrary Units) in rat ventral prostate [19]

subtotal

Low-Power Magnification

Luminal shape

regular (1); villous (3); papillary (4); cribriform (5)

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Acinar shape

tubular (1); branched (3); irregular (5)

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Interacinar shape

large or moderate (1); back-to-back glands (5)

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Stroma

fine (1); abundant (3); fibrosis/severe smooth muscle hyperplasia (5)

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High-Power Magnification

Epithelial shape :

flattened (1); cuboidal (1); cylindrical (3); hexagonal (5)

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Number of layers :

mono- (1); oligo, 2-4 (3); pluri, > 5 (5)

If > 1, then add: focal (3); diffuse (5)

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Alignment:

Polar (1); apolar (3)

If there is piling up of epithelial cells add (3)

If there is budding out of epithelial cells into stroma add (5)

If periacinar clusters of epithelial cells are found add (3)

If isolated clusters of epithelial cells are found outside acini add (5)

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Lesion distribution

Unilobar: isolated (2); multiple (6)

Bilobar: isolated (4); multiple (8)

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Nuclear shape:

Round, regular (1); irregular (5)

Small (2), large (2), small and large in the same acinus (4)

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Mitoses per field :

absent (0); isolated, 1-2 (2);

abundant, 3-5 (5); excessive, > 5 (10)

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Basement membrane:

Intact (1); interrupted (5)

Thin (1); thick (5)

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Total score (arbitrary units)

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