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Table 3 Comparison of the median and mean cytokine levels in the pleura fluid with the levels in the peripheral blood.

From: Cytokine & chemokine response in the lungs, pleural fluid and serum in thoracic surgery using one-lung ventilation

 

PLEURAL FLUID

RATIO OF CYTOKINE RESPONSE PLEURAL FLUID*

PERIPHERAL BLOOD

RATIO OF CYTOKINE RESPONSE PERIPHERAL BLOOD*

P VALUE#

PLEURAL FLUID VERSUS BLOOD

IL-6 (PG/ML), MEDIAN/MEAN (IQR)

     

   AT THORACOTOMY/INTUBATION

0/14 (0-21)

29.8

0/4 (0-10)

9.5

0.109

   END OF SURGERY

58/417 (22-396)

1950.6

16/38 (7-41)

24.8

0.085

   DAY 1

23448/27309 (12900-34929)

1889.9

54/99 (39-84)

10.5

<0.001

   DAY 2

11396/26458 (6510-18582)

914.3

28/42 (16-31)

11.0

<0.001

   DAY 3

4709/12800 (3590-19392)

 

13/44 (2-24)

 

<0.001

IL-1RA (PG/ML), MEDIAN/MEAN (IQR)

     

   AT THORACOTOMY/INTUBATION

9/46 (0-76)

5.8

75/470 (0-979)

1.2

0.102

   END OF SURGERY

140/267 (11-252)

440.8

134/580 (0-913)

1.6

0.525

   DAY 1

16239/20277 (10210-23527)

335.5

516/735 (0-1251)

1.1

<0.001

   DAY 2

8062/15435 (3477-15589)

261.3

112/492 (4-949)

1.1

<0.001

   DAY 3

4364/12018 (3152-13764)

 

147/524 (0-1184

 

<0.001

GROα (PG/ML), MEDIAN/MEAN (IQR)

     

   AT THORACOTOMY/INTUBATION

3/17 (0-30)

2.9

0/183 (0-257)

1.1

0.193

   END OF SURGERY

25/50 (7-57)

15.2

0/201 (0-224)

0.7

0.525

   DAY 1

172/258 (118-306)

11.2

0/136 (0-282)

0.6

0.017

   DAY 2

64/190 (25-179)

7.4

0/114 (0-145)

0.6

0.268

   DAY 3

97/125 (29-182)

 

0/105 (0-116)

 

0.389

  1. The pleural samples were taken immediately after the thoracotomy and before closure of the thoracotomy. On day 1-3 the pleural and peripheral blood samples were taken at the same time.
  2. *Concentration at intubation as base line for calculation of ratio (means used for calculation)
  3. # Wilcoxon paired samples test