Effect of an extra monoclonal antibody on the arthritogenicity of the 3-clone cocktail (CII-3, C2B-14, and CII-6). A: DBA/1J mice were given i.p. injections of a cocktail of CII-3, C2B-14, and CII-6, the cocktail plus C2A-12, the cocktail plus C2B-16 and the cocktail plus C2A-12 and C2B-16 on day 0 followed by an injection of LPS on day 3. B: DBA/1J mice received a new 4-clone cocktail (CII-3, C2B-14, CII-6, and C2A-12, total 2, 4 and 8 mg/mouse) on day 0 followed by LPS. Each value is the mean ± SEM for five animals.