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Figure 1 | Journal of Inflammation

Figure 1

From: Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells

Figure 1

IL-8 expression and production by "CF like" like (Solid bars)-and "wild-type like" cells (open bars) upon stimulation with IL-1β and/or TNFα. IL-8 mRNA expression was evaluated by real time-PCR. (A) IL-8 mRNA were significantly higher in AS cells at 3 and 6 h (p = 0.003 and p = 0.0002 respectively) and (B) in IB3-1 cells at 3 h (p = 0.0007). The media were also collected and subject to ELISA to determine IL-8 production. Similarly to the content of IL-8 mRNA, IL-8 protein were significantly high in AS cells at 3 and 6 h (p = 0.004 and p = 0.003 respectively) compared to S cells (A, inset).

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Journal of Inflammation

ISSN: 1476-9255

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