Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease

Journal of Inflammation

Table 3 Clinical characteristics of CKD patients with different ACE genotypes

	DD (n = 37)	II+ID (n = 39)	P-value
Age(Years)	11.21 ± 3.34	10.91 ± 4.51	0.78
SBP(mmHg)	130.96 ± 17.43	120.00 ± 14.04	0.04*
DBP(mmHg)	84.00 ± 12.24	84.00 ± 11.21	0.65
Total cholesterol(mg/dl)	187.71 ± 57.49	173.67 ± 38.91	0.25
Triglyceride(mg/dl)	154.15 ± 74.29	148.44 ± 40.81	0.36
HDL-cholesterol(mg/dl)	27.46 ± 12.81	24.13 ± 11.44	0.65
Creatinine(mg/dl)	6.20 ± 1.46	6.69 ± 1.41	0.42
Urea(mg/dl)	72.09 ± 22.35	68.87 ± 15.65	0.85
hs-CRP(mg/dl)	3.57 ± 3.37	2.71 ± 4.00	0.63
CK-MB(ng/ml)	5.78 ± 1.61	5.01 ± 1.21	0.63
Hypertensive%	89.19%	61.54%	0.02*
ACE activity(IU/l)	77.29 ± 58.10	50.10 ± 23.18	0.02*
Left ventricular mass index (g/m ^2.7 )	55.69 ± 10.47	51.38 ± 9.72	0.34
Severe left ventricular hypertrophy, n (%)	16(43.24%)	15(38.46%)	0.36

Significance was estimated using independent t-test. Data was means ± SD .SBP = systolic blood pressure, DBP = diastolic blood pressure, hs-CRP = high sensitivity C - reactive protein, CK-MB = creatine kinase-MB fraction. P < 0.05 was considered significant.

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