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Table 1 Various parameters in children with chronic kidney disease and control subjects

From: Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease

 

CT

(n = 32)

MHD

(n = 44)

Controls

(n = 70)

P value

Age(Years)

9.14 ± 7.59

10.62 ± 3.49

10.7 ± 4.51

0.14

Gender (M/F)

15 (46.88%)/17(53.12%)

24(54.55%)/20(45.45%)

40(57.14%)/30(42.86%)

0.30

BMI (kg/m 2 )

17.64 ± 1.17

18.89 ± 3.00

20.60 ± 1.44

0.71

SBP (mmHg)

98.66 ± 6.66

125.13 ± 16.36 b*

95.54 ± 9.70

0.01

Indexed SBP

0.90 ± 0.85

1.04 ± 0.14 b**

0.73 ± 0.05

0.001

DBP (mmHg)

64.66 ± 6.67

83.13 ± 12.76 b*

61.55 ± 10.10

0.01

Indexed DBP

0.90 ± 0.0.86

1.00 ± 0.10 b**

0.72 ± 0.05

0.001

Creatinine

(mg/dl)

3.93 ± 3.75 a*

6.30 ± 1.45 b**

0.73 ± 0.33

0.002

Predialysis urea, (mg/dl)

51.12 ± 10.45 a*

70.56 ± 19.61 b*

7.76 ± 2.53

0.02

e-GFR, ml/min/1/1.73 m2

15.41 ± 1.76 a**

11.30 ± 3.35 b**

86 ± 8.8

0.003

Dialysis, Yrs

 

2.73 ± 1.58

  

Kt/V

 

1.68 ± 0.40

  

Total cholesterol

(mg/dl)

164.44 ± 50.10ac**

192.04 ± 50.37 b*

161.31 ± 18.75

0.06

Triglycerides

(mg/dl)

160.78 ± 57.33 a**

146.00 ± 65.98 b**

63.31 ± 17.35

0.001

HDL- cholesterol (mg/dl)

21.35 ± 1.17a*

27.33 ± 9.87 b*

40.55 ± 7.83

0.01

hs-CRP

(mg/dl)

3.04 ± 3.24

3.62 ± 3.97 b*

1.35 ± 0.65

0.04

CK-MB (ng/ml)

6.23 ± 2.46 a*

5.26 ± 1.14

4.20 ± 0.20

0.04

ACE-activity(IU/l)

53.02 ± 22.44

70.47 ± 53.73 b**

30.11 ± 8.85

0.03

Left ventricular mass index (g/m 2.7 )

49 ± 5.20 a*

52.86 ± 10.10 b*

35.10 ± 8.12

0.04

Severe left ventricular hypertrophy, n (%)

6(18.75%)

25(56.82%)

  
  1. Data was evaluated by ANOVA test. Values were presented as means ± SD or percentage as applicable. CT = conservative treatment, MHD = maintenance hemodialysis, ACE = angiotensin converting enzyme, BMI = body mass index, SBP = systolic blood pressure, DBP = diastolic blood pressure, eGFR = estimated glomerular filtration rate, Kt/V = adequacy of hemodialysis, hs-CRP = high sensitivity C-reactive protein, CK-MB = creatine kinase-MB fraction. a*P < 0.05 or a**P < 0.01 vs. controls and CTb, *P < 0.05 or b**P < 0.01 vs. controls and MHD and, cP < 0.05 vs. CT and MHD.