Figure 4

5-hour fasting blood glucose (A), serum insulin (B), and HOMA-IR of WT and T4Mu mice that received LF and TF diets. Significant difference was determined with 2-way analysis of variance (genotype × diet type) for blood glucose, serum insulin, and HOMA-IR. Fasting blood glucose, serum insulin, and HOMA-IR are significantly higher in T4Mu mice compared to WT mice that received TF diet. Abbreviations: HOMA-IR, Homeostatic Model Assessment-Insulin Resistance; LF, low fat diet (13.5% energy from fat); T4Mu, toll-like receptor-4 loss of function mutant mice; TF, trans fat diet (60% of energy from fat, shortening-based); WT, wild type mice.