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Table 2 The effects of trichostatin A on Fas-induced eosinophil apoptosis.

From: Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

  Percentage of apoptotic cells
Control 47 ± 4
Fas 65 ± 2##
Fas +trichostatin A 3.3 nM 67 ± 3
Fas +trichostatin A 33 nM 79 ± 2***
Fas +trichostatin A 330 nM 89 ± 1***
  1. Shown is the percentage of apoptotic cells after 40 h incubation as analyzed by relative DNA fragmentation assay
  2. Values are the mean ± SEM of independent determinations using cells from different donors. n = 6. *** indicates P < 0.001 as compared with the respective solvent control in the absence of trichostatin A and ## P < 0.01 as compared with the respective control in the absence of Fas. The concentration of Fas activating antibody was 100 ng/ml.