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Table 1 The EC50 Values for the effects of trichostatin A on apoptosis in eosinophils and neutrophils.

From: Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

  EC50 (nM)  
Apoptosis Eosinophils neutrophils P value
GM-CSF    
   0.01 ng/ml 79 ± 2   
   0.1 ng/ml 102 ± 1   
   10 ng/ml 93 ± 1 123 ± 9 0.0042
IL-5 92 ± 8   
Constitutive 34 ± 10 97 ± 22 0.0007
Budesonide 32 ± 17 99 ± 7 0.026
Fluticasone 47 ± 15 100 ± 11 0.017
Mometasone 20 ± 5 87 ± 9 < 0.0001
Fas 31 ± 10   
  1. Values are the mean ± S.E.M. of six duplicate experiments with cells isolated from different donors.