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Table 1 The EC50 Values for the effects of trichostatin A on apoptosis in eosinophils and neutrophils.

From: Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

 

EC50 (nM)

 

Apoptosis

Eosinophils

neutrophils

P value

GM-CSF

   

   0.01 ng/ml

79 ± 2

  

   0.1 ng/ml

102 ± 1

  

   10 ng/ml

93 ± 1

123 ± 9

0.0042

IL-5

92 ± 8

  

Constitutive

34 ± 10

97 ± 22

0.0007

Budesonide

32 ± 17

99 ± 7

0.026

Fluticasone

47 ± 15

100 ± 11

0.017

Mometasone

20 ± 5

87 ± 9

< 0.0001

Fas

31 ± 10

  
  1. Values are the mean ± S.E.M. of six duplicate experiments with cells isolated from different donors.
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Journal of Inflammation

ISSN: 1476-9255

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