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Table 1 Effect of colitic inducers, TNBS and DSS, on lipid peroxide (malondialdehyde, MDA), 4-hydroxy-2-nonenal (4-HNE), and glutathione (GSH) contents and superoxide dismutase (SOD), and catalase activities in the colons of C3H/HeN and C3H/HeJ mice

From: Dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid induce lipid peroxidation by the proliferation of intestinal gram-negative bacteria in mice

 

Colitic inducer

Content

Activity

  

MDA (μM/mg)

4-HNE(ng/ml)

GSH(μg/ml)

SOD(Unit/mg)

Catalase(mol/min/mg)

C3H/HeN

-a

0.74 ± 0.51

0.86 ± 0.85

1.51 ± 1.14

3.76 ± 1.30

5.22 ± 1.33

 

DSS

5.60 ± 1.04#

11.92 ± 7.01#

4.53 ± 0.15#

1.06 ± 0.13#

0.19 ± 0.94#

C3H/HeJ

-a

0.72 ± 0.56

2.52 ± 3.11

0.67 ± 0.38

5.21 ± 1.83

6.25 ± 1.21

 

DSS

5.39 ± 1.00#

2.93 ± 2.26#

4.57 ± 0.12#

0.72 ± 0.17#

0.60 ± 1.41#

C3H/HeN

-a

0.99 ± 0.09

3.31 ± 0.15

4.92 ± 1.33

3.39 ± 0.34

7.53 ± 0.77

 

TNBS

5.11 ± 0.67#

15.92 ± 4.03#

2.19 ± 0.24#

0.16 ± 0.04#

1.49 ± 1.00#

C3H/HeJ

-a

0.66 ± 0.06

1.53 ± 1.80

4.38 ± 0.93

3.64 ± 0.47

4.76 ± 0.65

 

TNBS

2.95 ± 0.94#

3.57 ± 0.89#

2.13 ± 0.25#

0.50 ± 0.03#

0.82 ± 0.65#

  1. The test agents were orally administered once every day for 3 days prior to TNBS treatment. The mice were anesthetized with ether and killed 3 days after TNBS treatment.
  2. a) Normal group treated with vehicle alone instead of colitic inducer.
  3. All values are the mean ± S.D. (n = 10). #Significantly different vs normal group in each column of C3H/HeN or C3H/HeJ mice (P < 0.05).