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Table 4 Biomarker levels and organ dysfunction scores averaged over 72 hours by lactate clearance quartile.

From: Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock

  Quartile 1
N = 55
Quartile 2
N = 55
Quartile 3
N = 55
Quartile 4
N = 55
P-value
Biomarkers over 72 hours
   IL-1ra (ng/mL) 8455.9 ± 8838.4 7565.4 ± 8289.1 6421.3 ± 7957.5 2792.6 ± 3635.7 <0.01
   IL-6 (pg/mL) 2839.5 ± 3487.0 2680.1 ± 3174.0 2426.7 ± 3269.4 663.2 ± 1583.5 <0.01
   IL-8 (pg/mL) 480.3 ± 802.4 355.3 ± 559.1 356.3 ± 735.1 76.4 ± 218.0 <0.01
   IL-10 (pg/mL) 303.6 ± 298.7 227.4 ± 218.5 180.2 ± 243.4 85.4 ± 121.9 <0.01
   TNF-α (pg/mL) 65.2 ± 105.9 50.9 ± 69.2 47.4 ± 72.8 19.6 ± 19.8 <0.01
   ICAM-1 (ng/mL) 409.1 ± 208.1 413.3 ± 204.5 379.7 ± 213.8 299.2 ± 156.1 <0.01
   HMGB-1 (ng/mL) 4.6 ± 8.3 5.0 ± 10.4 2.5 ± 3.3 1.6 ± 2.4 <0.01
   D-Dimer (μ/mL) 20.8 ± 9.5 18.9 ± 9.5 18.1 ± 8.9 15.7 ± 9.7 0.04
   Caspase-3 (ng/mL) 3.8 ± 7.5 2.4 ± 3.8 1.9 ± 2.6 1.1 ± 0.8 <0.01
Organ dysfunction over 72 hours
   APACHE II 16.8 ± 6.3 16.6 ± 6.4 14.8 ± 6.9 11.6 ± 6.0 <0.01
   SAPS II 43.9 ± 12.4 44.6 ± 43.5 39.5 ± 12.0 34.2 ± 11.9 <0.01
   MODS 8.0 ± 3.5 7.0 ± 4.0 5.7 ± 4.2 3.4 ± 2.5 <0.01
   SOFA 8.8 ± 3.3 8.0 ± 3.4 6.8 ± 4.3 4.4 ± 2.7 <0.01
Outcome (%)
   In-hospital mortality 52.7 41.8 29.1 16.4 <0.01
   28-day mortality 54.9 49.0 33.5 21.6 <0.01
   60-day mortality 63.1 52.9 38.0 33.6 0.01
  1. Lactate clearance quartile - derived from sorting the study population by increasing lactate clearance and separating into four groups with equivalent number of patients. IL-1ra - interleukin-1 receptor antagonist; IL-6 - interleukin-6; IL-8 - interleukin-8; IL-10 - interleukin-10; TNF-α - tumor necrosis factor-α; ICAM-1 - intercellular adhesion molecule-1; HMGB-1 - high mobility group box-1; Acute Physiology and Chronic Health Evaluation (APACHE) II; Simplified Acute Physiology Score (SAPS) II; Multiple Organ Dysfunction Score (MODS); Sequential Organ Failure Assessment (SOFA).