Table 4 Biomarker levels and organ dysfunction scores averaged over 72 hours by lactate clearance quartile.
| Â | Quartile 1 N = 55 | Quartile 2 N = 55 | Quartile 3 N = 55 | Quartile 4 N = 55 | P-value |
|---|---|---|---|---|---|
Biomarkers over 72 hours | |||||
   IL-1ra (ng/mL) | 8455.9 ± 8838.4 | 7565.4 ± 8289.1 | 6421.3 ± 7957.5 | 2792.6 ± 3635.7 | <0.01 |
   IL-6 (pg/mL) | 2839.5 ± 3487.0 | 2680.1 ± 3174.0 | 2426.7 ± 3269.4 | 663.2 ± 1583.5 | <0.01 |
   IL-8 (pg/mL) | 480.3 ± 802.4 | 355.3 ± 559.1 | 356.3 ± 735.1 | 76.4 ± 218.0 | <0.01 |
   IL-10 (pg/mL) | 303.6 ± 298.7 | 227.4 ± 218.5 | 180.2 ± 243.4 | 85.4 ± 121.9 | <0.01 |
   TNF-α (pg/mL) | 65.2 ± 105.9 | 50.9 ± 69.2 | 47.4 ± 72.8 | 19.6 ± 19.8 | <0.01 |
   ICAM-1 (ng/mL) | 409.1 ± 208.1 | 413.3 ± 204.5 | 379.7 ± 213.8 | 299.2 ± 156.1 | <0.01 |
   HMGB-1 (ng/mL) | 4.6 ± 8.3 | 5.0 ± 10.4 | 2.5 ± 3.3 | 1.6 ± 2.4 | <0.01 |
   D-Dimer (μ/mL) | 20.8 ± 9.5 | 18.9 ± 9.5 | 18.1 ± 8.9 | 15.7 ± 9.7 | 0.04 |
   Caspase-3 (ng/mL) | 3.8 ± 7.5 | 2.4 ± 3.8 | 1.9 ± 2.6 | 1.1 ± 0.8 | <0.01 |
Organ dysfunction over 72 hours | |||||
   APACHE II | 16.8 ± 6.3 | 16.6 ± 6.4 | 14.8 ± 6.9 | 11.6 ± 6.0 | <0.01 |
   SAPS II | 43.9 ± 12.4 | 44.6 ± 43.5 | 39.5 ± 12.0 | 34.2 ± 11.9 | <0.01 |
   MODS | 8.0 ± 3.5 | 7.0 ± 4.0 | 5.7 ± 4.2 | 3.4 ± 2.5 | <0.01 |
   SOFA | 8.8 ± 3.3 | 8.0 ± 3.4 | 6.8 ± 4.3 | 4.4 ± 2.7 | <0.01 |
Outcome (%) | |||||
   In-hospital mortality | 52.7 | 41.8 | 29.1 | 16.4 | <0.01 |
   28-day mortality | 54.9 | 49.0 | 33.5 | 21.6 | <0.01 |
   60-day mortality | 63.1 | 52.9 | 38.0 | 33.6 | 0.01 |