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Table 3 Therapies during the first 6 hours in the ED and from 7 to 72 hours in the ICU by lactate clearance quartile.

From: Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock

  Quartile 1
N = 55
Quartile 2
N = 55
Quartile 3
N = 55
Quartile 4
N = 55
P-value
Therapies in first 6 hours
   Antibiotics (%) 72.2 77.5 72.1 75.0 0.95
   Appropriate Antibiotics (%) 86.3 77.5 90.7 88.9 0.59
   Fluids (mL) 4531.2 ± 2745.3 4263.5 ± 2872.9 4266.8 ± 3449.5 3741.7 ± 3136.4 0.27
   Transfusion (%) 54.6 41.8 26.4 43.6 0.27
   Vasopressor (%) 50.9 36.4 27.3 14.6 <0.01
   Inotrope/dobutamine (%) 5.5 3.6 9.1 12.7 0.29
   Mechanical ventilation (%) 74.6 50.9 58.2 38.2 <0.01
Therapies from 7 to 72 hours
   Antibiotics (%) 95.0 93.9 100 97.0 0.50
   Fluids (mL) 8817.2 ± 5818.1 9666.7 ± 6555.2 10329.8 ± 6866.6 7141.9 ± 4097.8 0.06
   Transfusion (%) 23.6 20.0 20.0 27.3 0.77
   Vasopressor (%) 47.3 47.3 30.9 18.2 <0.01
   Inotrope/dobutamine (%) 10.9 14.6 9.1 12.7 0.83
   Mechanical ventilation (%) 12.7 14.6 7.3 7.3 0.48
  1. Lactate clearance quartile - derived from sorting the study population by increasing lactate clearance and separating into four groups with equivalent number of patients.