Figure 3
From: HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression
Effect of HE3286 on OVA-specific immunoglobulin production. Female BALB/c mice (5 per group) were sensitized by intraperitoneal injection (total volume 200 μL) on days 1 and 8 with 100 μg OVA precipitated with alum (25 mg/mL) in saline. Animals were treated (gavage) with HE3286 (40 mg/kg) or with HERF202 vehicle (100 μL) alone once daily for twenty days. On day twenty, animals were sacrificed and OVA-specific immunolglobulin (IgG) levels in serum were measured at various dilutions by ELISA. Data are expressed as optical density +/- standard deviation on the Y-axis versus dilution on the X-axis.