Figure 1

Effect of HE3286 treatment on carrageenan-induced pleurisy. Mice CD1 mice (10 per group) were anesthetized and saline (0.1 mL) alone (sham) or saline containing 2% carrageenan (CAR) was injected into the pleural cavity. Mice were treated (sc) with HE3286 (4 or 40 mg/kg) or vehicle HERF405 alone (0.1 mL) 24 h before and 1 h before CAR. At 4 h after CAR, the animals were killed, the chest opened, and the pleural cavity rinsed with 1 mL of saline solution. The leukocytes in the exudate were suspended in phosphate-buffer saline (PBS) and counted. Data are expressed as mL exudate volume (A) or millions of neutrophils (B) per mouse +/- standard deviation on the Y-axis. Treatment groups are identified on the X-axis. *p < 0.05.