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Figure 3 | Journal of Inflammation

Figure 3

From: Defining human mesenchymal stem cell efficacy in vivo

Figure 3

Xenographic Effect of hMSCs on Total Cell Recruitment. Animals were sensitized with ovalbumin and challenged with saline followed by BAL. The total differential cell count between saline-challenged mice and naive controls was negligible (data not shown). hMSC exposure decreased the total cell count in the BAL of the ovalbumin-challenged mice (Figure 3A, p = 0.03, n = 5), but increased the total cell count in the saline-challenged mice (Figure 3A, p < 0.05 for the saline control versus saline control with husks). Further, the hMSCs altered the inflammatory phenotype of the saline control animal (3B, n = 4, p < 0.05) suggesting that the hMSCs can induced a cellular response in the absence of ovalbumin-induced inflammation in the context of an acute response. The change in the inflammatory status did not impact the immediate histology of the acute treated model (3C:40× and 3D:hMSC, 40×). Histology is representative of 5 different experiments with n = 6-8 in each group.

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