Figure 3From: Defining human mesenchymal stem cell efficacy in vivoXenographic Effect of hMSCs on Total Cell Recruitment. Animals were sensitized with ovalbumin and challenged with saline followed by BAL. The total differential cell count between saline-challenged mice and naive controls was negligible (data not shown). hMSC exposure decreased the total cell count in the BAL of the ovalbumin-challenged mice (Figure 3A, p = 0.03, n = 5), but increased the total cell count in the saline-challenged mice (Figure 3A, p < 0.05 for the saline control versus saline control with husks). Further, the hMSCs altered the inflammatory phenotype of the saline control animal (3B, n = 4, p < 0.05) suggesting that the hMSCs can induced a cellular response in the absence of ovalbumin-induced inflammation in the context of an acute response. The change in the inflammatory status did not impact the immediate histology of the acute treated model (3C:40× and 3D:hMSC, 40×). Histology is representative of 5 different experiments with n = 6-8 in each group.Back to article page