Figure 9From: Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 proteinfeG and asthma in sheep: In asthmatic sheep naturally sensitized to Ascaris suum, bronchoconstriction determined by measuring specific lung resistance (SRL) increased rapidly immediately after aerosol challenge, decreased to baseline values over 4 hours, but was followed by a secondary increase in SRL 5 after hours post challenge. Inhaled feG at a dose of 30 mg/sheep reduced early as well as late increases in SRL, whereas treatment with feG intravenously (1 mg/kg) or orally (2 mg/kg) inhibited only late phase bronchoconstriction. (mean ± sem, n = 4 to 8). Adapted from [51].Back to article page