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Figure 3 | Journal of Inflammation

Figure 3

From: Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Figure 3

CP-690,550 inhibits the increase in bone marrow myeloid precursors in the rat AIA model. Bone marrow from normal and AIA rats (n = 12 rats per group) was analyzed for maturing myeloid precursors by flow cytometry at day 7 and day 21 post-adjuvant immunization (A). (*) indicates statistical significance p ≤ 0.0008 compared to normal animals. AIA rats were treated with CP-690,550 or vehicle control orally, once daily, days 14 to 21, and bone marrow was collected and analyzed on day 21 for maturing myeloid cells by flow cytometry (B). (*) indicates statistical significance p ≤ 0.05 compared to the disease vehicle control. Data represented as the mean ± SEM.

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Journal of Inflammation

ISSN: 1476-9255

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