Peripheral blood neutrophil count and the inflammatory cytokines IL-6 and IL-17 increase with disease in the rat AIA model. Normal and AIA rats (n = 12 rats per group per timepoint) were characterized temporally post-adjuvant immunization. Hind paw volume was measured by volume displacement as an indication of joint arthritis, days 13 to 26 (A). Peripheral blood neutrophils were quantitated using a Cell-Dyne 3700 analyzer, days -1 to 21 (B). IL-17 (C) and IL-6 (D) were quantitated using immunoassays, days -1 to 21. (*) indicates statistical significance p ≤ 0.04 compared to normal controls. Data represented as the mean ± SEM.