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Table 2 Mean (± sd) concentrations (mcg/ml) of linezolid and ertapenem in blood serum (Cserum) and pleural fluid (Cpf) after the iv administration of a linezolid solution (10 mg/kg infused over a period) and an ertapenem solution (60 mg/kg infused over a period), to 10 and 8 New Zealand white rabbits, respectively

From: Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion

 

1 h

2 h

4 h

6 h

8 h

Linezolid

Cserum

2.10 ± 1.20

0.20 ± 0.28

< QL

< QL

< QL

N

10

10

9

7

7

Cpf

1.28 ± 1.60

2.02 ± 0.73*

1.70 ± 1.00

0.79 ± 0.85

0.16 ± 0.25

N

10

9

9

7

6

Ertapenem

Cserum

6.26 ± 2.98

2.80 ± 1.64

0.97 ± 1.09

0.79 ± 0.85

0.39 ± 0.25

N

8

8

8

7

6

Cpf

3.00 ± 1.55*

3.74 ± 1.39*

3.62 ± 1.40*

3.16 ± 1.20*

2.84 ± 0.90*

N

8

8

7

7

5

  1. N = number of experimental animals, QL: estimations are lower than the analytical quantification limit. *: significantly different values from the corresponding pleural fluid ones (p < 0.05. student's t-test).
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Journal of Inflammation

ISSN: 1476-9255

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