Skip to main content

Table 2 Mean (± sd) concentrations (mcg/ml) of linezolid and ertapenem in blood serum (Cserum) and pleural fluid (Cpf) after the iv administration of a linezolid solution (10 mg/kg infused over a period) and an ertapenem solution (60 mg/kg infused over a period), to 10 and 8 New Zealand white rabbits, respectively

From: Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion

  1 h 2 h 4 h 6 h 8 h
Linezolid
Cserum 2.10 ± 1.20 0.20 ± 0.28 < QL < QL < QL
N 10 10 9 7 7
Cpf 1.28 ± 1.60 2.02 ± 0.73* 1.70 ± 1.00 0.79 ± 0.85 0.16 ± 0.25
N 10 9 9 7 6
Ertapenem
Cserum 6.26 ± 2.98 2.80 ± 1.64 0.97 ± 1.09 0.79 ± 0.85 0.39 ± 0.25
N 8 8 8 7 6
Cpf 3.00 ± 1.55* 3.74 ± 1.39* 3.62 ± 1.40* 3.16 ± 1.20* 2.84 ± 0.90*
N 8 8 7 7 5
  1. N = number of experimental animals, QL: estimations are lower than the analytical quantification limit. *: significantly different values from the corresponding pleural fluid ones (p < 0.05. student's t-test).