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Table 2 Time kinetics of metabolic and organ specific parameters

From: Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model

 

0 h

End shock

24 h

48 h

72 h

 

SMC

LIM

SMC

LIM

SMC

LIM

SMC

LIM

SMC

LIM

Lactate

3.3 ± 0.26

3.4 ± 0.38

3.4 ± 0.28

4.0 ± 0.43a

n.d.

n.d.

2.1 ± 0.39

2.4 ± 0.78

2.3 ± 0.22a

1.6 ± 0.31a

BE

3.1 ± 0.58

5.0 ± 0.57b

1.4 ± 0.91

1.4 ± 0.71a

n.d.

n.d.

4.3 ± 0.58

4.8 ± 1.59

5.2 ± 0.92

6.1 ± 1.05

Creatinine [1.1-1.8]

1.0 ± 0.03

0.9 ± 0.05b

1.0 ± 0.05

0.9 ± 0.06

1.2 ± 0.07a

1.2 ± 0.16

0.9 ± 0.09

1.1 ± 0.18

1.1 ± 0.06

0.8 ± 0.04b

AST [23-54]

56 ± 6.8

40 ± 2.8

37 ± 4a

31 ± 2.91

912 ± 193a

1853 ± 572a

378 ± 120a

854 ± 515a

62 ± 6.8

64 ± 9.7

ALT [50-90]

60 ± 5.68

51.1 ± 3.0

31 ± 3.3a

26 ± 1.28a

203 ± 25.3a

258 ± 33.8a

178 ± 19.2a

213 ± 30.0a

108 ± 5.84a

123 ± 16.5a

CK [251-810]

1643 ± 220

1183 ± 87

982 ± 134a

716 ± 56a

58420 ± 9767a

77653 ± 14960a

15851 ± 4185a

29439 ± 15529a

2338 ± 233

1431 ± 305b

CK-MB

180 ± 20

151 ± 6

95 ± 13a

97 ± 10a

767 ± 84a

969 ± 144a

294 ± 33

467 ± 152a

156 ± 12a

134 ± 31

Troponin T [< 0.05]

0.03 ± 0.01

0.02 ± 0.003

0.04 ± 0.01

0.04 ± 0.01a

0.08 ± 0.03

0.15 ± 0.05a

0.02 ± 0.004

0.04 ± 0.021

0.02 ± 0.006

0.01 ± 0.00

  1. Reference Ranges in []. Lactate [mmol/l]; BE [mmol/l]: base excess; creatinine [mg/dl]; AST [U/l]: aspartate aminotransaminase; ALT [U/l]: alanine aminotransaminase; CK [U/l]: creatine phosphokinase; CK-MB [U/l]: „MB"-type isoenzyme of creatine phosphokinase; Troponin T [ng/ml]; n = 12 per group, 72 h n = 6; Mean ± SEM; a-statistically significant (p < 0.05) over-time; b-statistically significant (p < 0.05) between SMC and LIM group. n.d. = not determined.