Skip to main content

Table 3 Clinical/biochemical characteristics of NAFLD patients on diet and Orlistat treatment

From: Elevated endotoxin levels in non-alcoholic fatty liver disease

  Diet alone Diet and Orlistat
  Baseline 6 months 12 months Baseline 6 months 12 months
Age (years) 48.8 ± 11.5    53.4 ± 16   
Body weight (kg) 100.0 ± 16.1 100.8 ± 16.3 101.6 ± 16.3 100.9 ± 24.5 95.5 ± 24.4 * 96.4 ± 25.7 *
Endotoxin (EU/mL) 15.9 ± 7.2 16.7 ± 5.5 14.4 ± 11.0 15.8 ± 4.6 14.4 ± 5.7 11.1 ± 4.0 **
sCD14 (μg/mL) 1.52 ± 0.40 2.46 ± 0.19 2.25 ± 1.28 1.45 ± 0.60 1.55 ± 0.35 1.59 ± 0.69
Glucose (mmol/L) 6.5 ± 2.4 6.1 ± 1.7 8.2 ± 3.8 5.6 ± 0.9 5.3 ± 0.7 5.4 ± 1.4
Insulin (μU/mL) 24.2 ± 20.2   21.2 ± 9.5 22.6 ± 13.5   21.6 ± 13.1
HOMA-IR 3.2 ± 2.6   3.0 ± 1.3 2.9 ± 1.8   2.8 ± 1.6
ALT (U/L) 129 ± 86 90 ± 67 100 ± 68 93 ± 31 60 ± 20 ** 66 ± 41
Cholesterol (mmol/L) 4.9 ± 0.8 4.8 ± 1.4 4.7 ± 1.1 5.1 ± 1.4 4.6 ± 1.6 4.9 ± 1.7
LDL-cholesterol (mmol/L) 2.8 ± 0.8 3.0 ± 1.2 2.8 ± 1.0 3.1 ± 1.3 2.7 ± 1.4 2.8 ± 1.6
HDL-cholesterol (mmol/L) 1.09 ± 0.17 1.62 ± 0.58 1.68 ± 1.35 1.16 ± 0.26 1.38 ± 0.39 1.23 ± 0.36
Triglycerides (mmol/L) 2.4 ± 1.3 2.3 ± 1.0 2.4 ± 1.6 1.9 ± 0.6 1.7 ± 0.6 1.9 ± 0.7
  1. NAFLD patients underwent a 12 month course of intensive diet-treatment with (n = 8) or without) Orlistat (n = 6). Data are mean (± SD). * p < 0.005 (versus baseline), ** p < 0.05 (versus baseline).