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Table 2 Clinical and biochemical characteristics of NAFLD Compared with NASH Subjects.

From: Elevated endotoxin levels in non-alcoholic fatty liver disease

  NAFLD NASH P-value
NAFLD Vs NASH
Age (yrs) 47.2 ± 11.1 50.4 ± 13.3 NS
BMI (kg/m 2 ) 32.6 ± 5.7 35.0 ± 6.0 p < 0.05
Endotoxin (EU/mL) # 12.3(7.3, 15.6) 10.9(7.8, 13.9) NS
Fibrosis score: 0 12.3(6.6, 17.2) 8.6(5.5, 11.7)  
1 13.3(11.1, 15.6) 11.7(8.0, 17.2)  
2 7.1(7.1, 7.1) 11.7(8.2, 15.0)  
3 NA 12.6(9.4, 14.5)  
4 NA 8.2(5.2, 11.2)  
Insulin (μU/mL) # 18.3(8.1, 22.3) 30.4(14.6, 36.3) p < 0.001
Fibrosis score: 0 16.7(8.1, 21.1) 29.1(9.8, 26.2)  
1 37.2(8.7, 76.3) 26.8(14.2, 33.4)  
2 NA 27.4(16.3, 36.9)  
3 NA 38.6(18.4, 67.2)  
4 NA 37.0(17.6, 54.8)  
Glucose (mmol/L) # 5.5(4.8, 6.1) 6.6(4.8, 7.0) p = 0.01
Fibrosis score: 0 5.4(4.8, 5.9) 6.9(4.5, 6.2)  
1 6.6(4.8, 8.3) 5.5(4.7, 5.8)  
2 6.7(6.7, 6.7) 5.7(4.5, 6.4)  
3 NA 8.0(5.5, 9.2)  
4 NA 8.2(5.0, 10.8)  
HOMA-IR # 4.8(1.7, 5.6) 8.6(3.3, 13.3) p < 0.001
Fibrosis score: 0 4.1(1.7, 5.4) 7.4(1.9, 7.3)  
1 12.4(1.8, 27.0) 7.0(3.0, 8.6)  
2 NA 6.9(3.3, 9.1)  
3 NA 12.8(4.4, 22.5)  
4 NA 12.7(7.0, 21.9)  
TNF-α (pg/mL) # 8.3(4.2, 7.3) 14.7(5.0, 8.9) p < 0.05
Fibrosis score: 0 8.6(4.2, 7.4) 7.4(4.7, 8.0)  
1 6.0(4.0, 8.9) 16.6(5.1, 6.9)  
2 6.3(6.3, 6.3) 8.5(4.9, 10.6)  
3 NA 43.7(4.4, 21.6)  
4 NA 6.7(4.7, 9.0)  
sCD14 (ng/mL) # 1575.0(1242.6, 1840.8) 1805.2(1374.8, 2169.6) p = 0.01
Fibrosis score: 0 1533.3(1224.6, 1809.2) 1716.0(1331.1, 2018.2)  
1 1851.2(1319.3, 2408.3 1642.2(1302.1, 1857.5)  
2 1747.1(1747.1, 1747.1) 1829.3(1558.2, 2253.3)  
3 NA 1870.0(1680.2, 2080.5)  
4 NA 2000.3(1361.0, 2460.1)  
sTNFRII (pg/mL) # 2097.3(1642.42453.7) 2676.9(2075.6, 3034.2) p < 0.001
Fibrosis score: 0 2062.9(1621.2, 2445.0) 2491.0(2076.8, 2377.6)  
1 2292.8(1729.0, 3067.5) 2330.2(1991.2, 2752.2)  
2 2494.9(2494.9, 2494.9) 2597.2(1833.7, 3341.7)  
3 NA 2688.9(1962.0, 3047.1)  
4 NA 3538.0(2558.3, 4229.2)  
  1. Data are presented as mean (± SD) unless log transformed (#) in which case they are presented as mean (interquartile range). NA refers to no data available as there were no subjects in this group.