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Figure 5 | Journal of Inflammation

Figure 5

From: Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro

Figure 5

Blockade of IL-8/CXCL8-induced cell migration by arachidonyl trifluoromethylketone (TFMK) or pyrrophenone. PMNs were pretreated with 1 ÎĽM - 30 ÎĽM TFMK or 10-9 M - 10-6 M pyrrophenone for 30 min prior to IL-8/CXCL8 exposure. PMN migration was assessed by measuring the total myeloperoxidase activity in the neutrophil fraction (see Methods section). Data are expressed as % cell migration from N = 6 isolations. *P < 0.05; **P < 0.01 as indicated.

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