Anti-inflammatory activity of nanocrystalline silver-derived solutions in porcine contact dermatitis

Journal of Inflammation

Table 4 Statistical analysis of immunohistochemical staining scores*.

Cytokine/Growth Factor	Time (h)	ANOVA	Post Test Results
TNF-α	24 h	p = 0.3582	No significant differences.
TNF-α	72 h	p = 0.0004	pH 7 < pH 4 (p < 0.05)
			pH 9 < pH 4 (p < 0.05)
			pH 7 < Positive Control (p < 0.01)
			pH 9 < Positive Control (p < 0.01)
			Negative Control < Positive Control (p < 0.05)
IL-8	24 h	p = 0.1742	No significant differences.
IL-8	72 h	p = 0.0492	pH 5.6 < Positive Control (p < 0.05)
IL-4	24 h	p = 0.0248	Negative Control < pH 9 (p < 0.05)
IL-4	72 h	p = 0.0026	Negative Control < pH 4 (p < 0.05)
			Negative Control < pH 5.6 (p < 0.01)
			Negative Control < pH 7 (p < 0.01)
			Negative Control < pH 9 (p < 0.01)
EGF	24 h	p = 0.0031	Negative Control < pH 9 (p < 0.01)
			Positive Control < pH 9 (p < 0.05)
			pH 4 < pH 9 (p < 0.01)
			pH 7 < pH 9 (p < 0.01)
EGF	72 h	p = 0.0199	No significant differences.
KGF	24 h	p = 0.0039	Negative Control < pH 9 (p < 0.05)
			Positive Control < pH 9 (p < 0.05)
			pH 4 < pH 9 (p < 0.05)
			pH 7 < pH 9 (p < 0.05)
			pH 7 < pH 5.6 (p < 0.05)
KGF	72 h	p = 0.1310	No significant differences.
KGF-2	24 h	p = 0.0105	pH 7 < pH 9 (p < 0.05)
			Negative Control < pH 9 (p < 0.05)
KGF-2	72 h	p = 0.0173	Negative Control < pH 5.6 (p < 0.05)
			Negative Control < pH 7 (p < 0.05)
IL-10	24 h	p = 0.6472	No significant differences.
IL-10	72 h	p = 0.8397	No significant differences.

*Statistical analyses were performed using one-way ANOVAs with Tukey-Kramer Multiple Comparisons Post Tests. All treatment groups were compared in an ANOVA, and if the ANOVA indicated significant differences were present between groups, each treatment group was compared to every other treatment group in post testing. Only statistically significant post test results are shown. Any treatment group comparisons not listed were not significantly different from one another (p > 0.05).

ISSN: 1476-9255