Figure 8
From: Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs
Hypothesized mechanism of CS-impaired VEGFR2-mediated survival signaling. CS decreases VEGFR2 levels thereby alters the survival signaling via PI-3K. Downregulation of VEGFR2-PI-3 K-Akt pathways will lead to reduction of eNOS and NO bioavailability as well as reduced survival signaling via increasing the Bad-Bcl-xL interaction.