Effect of CS on Akt phosphoryaltion. (A) A representative immunoblot picture of Akt phosphorylation after 3 days, 8 weeks and 6 months of CS exposure in rat lungs. Akt phosphorylation was significantly reduced both at 8 weeks and 6 months, but not after 3 days of CS exposure, compared to sham-exposed animals (n = 6). (B) Histograms represent the Mean ± SE of percentage of Akt phosphorylation. *** p < 0.001 compared to sham-exposed animals.