Figure 3
From: Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis
Effect of NaHS treatment on pancreatitis associated lung injury in acute pancreatitis. A. MPO activity in lung. Acute pancreatitis was induced by intraperitoneal administration of caerulein ((50 μg/kg hourly, for 10 h). Column labeled 'CTRL' refers to lung MPO activity in mice injected intraperitoneal saline (not caerulein) as control. Column labeled 'Veh+Cae', 'N5+Cae', 'N10+Cae', 'N15+Cae' refers pretreatment with vehicle or different dosages of NaHS (5 mg/kg, 10 mg/kg or 15 mg/kg respectively) administered intraperitoneal 1 h before the first injection of caerulein. Results shown are the mean ± SEM for 8-10 animals in each group. Asterisk (*): P < 0.05 c.f. control (saline) group. Asterisk (#): P < 0.05 c.f. (Veh + Cae) group. Abbreviations used: CTRL: Control; Cae: Caerulein; Veh: Vehicle; N: NaHS. B. Lung Histology: i, Lung section from control (saline injected) animal; ii, Lung section from caerulein-induced pancreatitis pretreated with DW (vehicle) only; arrow showing alveolar thickening and inflammatory cells infiltration. iii, pretreated with NaHS (5 mg/kg);iv, pretreated with NaHS (10 mg/kg); v, pretreated with NaHS (15 mg/kg).