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Figure 2 | Journal of Inflammation

Figure 2

From: Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis

Figure 2

A: Effect of NaHS treatment on pancreatic myeloperoxidase (MPO). Acute pancreatitis was induced by intraperitoneal administration of caerulein ((50 μg/kg hourly, for 10 h). Column labeled 'CTRL' refers to pancreas MPO activity in mice injected intraperitoneal saline (not caerulein) as control. Column labeled 'Veh+Cae', 'N5+Cae', 'N10+Cae', 'N15+Cae' refers pretreatment with vehicle or different dosages of NaHS (5 mg/kg, 10 mg/kg or 15 mg/kg respectively) administered intraperitoneal 1 h before the first injection of caerulein. Results shown are the mean ± SEM for 8-10 animals in each group. Asterisk (*): P < 0.05 c.f. CTRL group. Asterisk (#): P < 0.05 c.f. (Veh + Cae) group. Abbreviations used: CTRL: Control; Cae: Caerulein; Veh: Vehicle; N: NaHS. B. Pancreas histology: i, Control (saline injected) pancreas; ii, caerulein-induced pancreatitis pretreated with DW (vehicle) only; arrow showing oedema, and infiltration of inflammatory cells. iii, pretreated with NaHS (5 mg/kg);iv, pretreated with NaHS (10 mg/kg); v, pretreated with NaHS (15 mg/kg).

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