Gadolinium chloride does not decrease IL-8/CINC-1 production in the myocardium or serum during ischemia and reperfusion. Rats were either treated with vehicle or GdCl3 either before 30 min ischemia and 120 min reperfusion or a Sham procedure. (Ischemia) and (Reperfusion) in the Sham groups is equal to the time period that correlates with Ischemia and Reperfusion in the Control and GdCl3 groups. IL-8/CINC-1 was measured from the serum at 30 min ischemia and 120 min reperfusion and from the tissue at 120 min reperfusion. A) Quantitation of tissue IL-8/CINC-1 B) Quatitation of serum IL-8/CINC-1. Data mean ± SD, n = 3-4/gp, * = p < 0.05 vs. perfusion. No significant difference between IR vs. Sham groups or Control vs. GdCl3 groups.