Figure 8From: CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitisChronic MK0812 treatment inhibits the accumulation of monocytes, macrophages and other leukocyte populations in the CNS. A, Leukocytes were isolated from naïve mice or mice immunized with MOG35-55 and dosed with MK0812 (30 mg/kg, b.i.d., p.o.) or MC as in Figure 7. Leukocyte isolations were performed between days 14-21, when clinical disease was evident in the EAE/MC group. The number of monocytes, macrophages, microglia, T lymphocytes and neutrophils were calculated based on flow cytometric analyses using the indicated combinations of cell surface markers. Cell numbers indicated are total cells per mouse. **p < 0.01 and *p < 0.05 compared to MC group. The data presented are the mean ± S.E.M. of five mice per group and are representative of two independent experiments.Back to article page