Skip to main content
Figure 8 | Journal of Inflammation

Figure 8

From: CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis

Figure 8

Chronic MK0812 treatment inhibits the accumulation of monocytes, macrophages and other leukocyte populations in the CNS. A, Leukocytes were isolated from naïve mice or mice immunized with MOG35-55 and dosed with MK0812 (30 mg/kg, b.i.d., p.o.) or MC as in Figure 7. Leukocyte isolations were performed between days 14-21, when clinical disease was evident in the EAE/MC group. The number of monocytes, macrophages, microglia, T lymphocytes and neutrophils were calculated based on flow cytometric analyses using the indicated combinations of cell surface markers. Cell numbers indicated are total cells per mouse. **p < 0.01 and *p < 0.05 compared to MC group. The data presented are the mean ± S.E.M. of five mice per group and are representative of two independent experiments.

Back to article page